If when you expand items the same plugin appears multiple times in your report or simply takes a long time to load in the GTmetrix waterfall tab you should probably delete or replace that plugin... . And instead of using Jetpack so you can use 1 or 2 features install a lightweight plugin that does the same thing but doesn't have a million settings features that will slow down your site.. . You can also read my own WordPress speed optimization guide which includes over 30 ways to make your site load faster using WP Rocket Cloudflare AMP Pages image optimization plugin optimizations and plenty more which has over 200+ comments.. It also has options for heartbeat control if you remember the actual heartbeat control plugin you can now delete it and just use this. as well as a few other options that can speed up your website admin panel. Since P3 Profiler doesn't work anymore an alternative solution to finding YOUR slowest loading plugins is to run your site through GTmetrix and check out your report.
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